ACTION AND USE. Primaquine phos-
phate is the drug of choice for the prevention or
relapse of malaria caused by P. vivax, and P.
ovale. Primaquine phosphate is contraindicated
in G-6-PD deficient personnel as it may result in
USUAL DOSE. Primaquine phosphate is
most commonly used as a terminal prophylaxis,
i.e., it is given for 14 days after leaving an endemic
Fansidar (Sulfadoxine and Pyrimethamine)
ACTION AND USE. Fansidar is used in the
curative treatment of strains of malaria that are
resistant to chloroquine phosphate. It is also used
as a prophylaxis in endemic areas.
USUAL DOSE. For the curative treatment,
2 or 3 tablets followed by two weeks of prima-
quine phosphate to prevent relapse. For the
prophylactic treatment, one tablet weekly begin-
ning two days prior to arrival in an endemic area
and six weeks after leaving the area followed by
a regimen of primaquine phosphate.
ACTION AND USE. Mebendazole is effec-
tive in treating infestations of hookworm, round-
worm, pinworm, and whipworm.
USUAL DOSE. For pinworms, a single 100
mg tablet is generally sufficient to effect cure. For
whipworms, roundworms, and hookworms, a 100
mg tablet morning and evening for three con-
Pyrantel Pamoate (Antiminth)
ACTION AND USE. This is regarded as the
drug of choice for pinworm and roundworm
USUAL DOSE. A single dose of 1 ml (50
mg) per pound body weight. It maybe admin-
istered without regard to ingestion of food or time
ACTION AND USE. Thiabendazole is a
vermacide used to destroy pinworms, round-
worms, threadworms, hookworms, and whip-
worms. It is not indicated as a prophylactic agent.
USUAL DOSE. The dosage is based on the
patients weight. For persons over 150 pounds,
1.5 g two times daily for two days. For persons
under 150 pounds, dosage is 10 mg per pound two
times daily. The maximum daily dosage is 3.0 g.
Pyrvinium Pamoate (Povan)
ACTION AND USE. Pyrvinium pamoate is
indicated in the treatment of pinworms. To avoid
undue concern, the patient should be informed
that the drug will stain a bright red and stools will
be a bright red.
USUAL DOSE. Pyrvinium pamoate is ad-
ministered in a single dose of 5 mg/kg body weight
up to a maximum of 7 tablets of 50 mg each.
Laxatives are drugs that facilitate the passage
and elimination of feces from the colon and rec-
tum. They are indicated for the treatment of sim-
ple constipation and to clean the intestine of any
irritant or toxic substances (catharsis). Laxatives
may also be used to soften painfully hard stools
and to lessen straining of certain cardiac patients
when defecating. They are contraindicated in cer-
tain inflammatory conditions of the bowel, bowel
obstruction, and abdominal pain of unknown
origin, and should not be used in the presence of
nausea and vomiting. Laxatives are classified as
irritant, bulk, emollient, or stool softeners. Fre-
quent or prolonged use of any laxative may result
ACTION AND USE. Mineral oil is an
emollient laxative used to lubricate the fecal mass.
It is often used in combination with an irritant
agent such as phenophthalein.
USUAL DOSE. 15 to 45 ml at bedtime.
Glycerin Suppositories NF
ACTION AND USE. These are widely used
in children. They promote peristalsis through local
irritation of the mucous membrane of the colon.