Tolnaftate (Tinactin, Aftate)
ACTION AND USE. Tolnaftate was the
first fungicide synthesized. It is effective in the
treatment of superficial fungal infections of the
skin. It is indicated for the topical treatment of
tinca pedis (athletes foot), tinca corporis (body
ringworm), tines capitis (fungus infection of the
scalp), and tines versicolor.
USUAL DOSE. It is for topical use only and
is available in cream, gel, powder, and solution.
Only small quantities are required for effective
treatment. Apply twice daily to the affected area
for 2 to 3 weeks.
Clotrimazole (Lotrimin, Mycelex)
ACTION AND USE. This is a broad-
spectrum antifungal that inhibits the growth of
pathogenic dermatophytes, yeasts, and other types
of fungus growth, including Candida albicans. It
is indicated for the treatment of tinea pedis, tinea
cruris, tines corporis, and candidiasis.
USUAL DOSE. It is for topical use only. It
is available in cream and solution. It is also
available in a vaginal cream for the treatment of
vulvovaginal candidiasis. Apply twice daily to the
affected area for two weeks. A single daily vaginal
application for two weeks is generally sufficient
Parasitic infections or infestations account for
the largest number of chronic disabling diseases
known. They are especially prevalent in the tropics
or subtropics and in lesser developed countries
where overcrowding and poor sanitation exist.
Parasitic infections include protozoal infections,
i.e., malaria, amebiasis, and to a lesser extent,
trichomoniasis; helminthic infections (intestinal
worms), and ectoparasites. Ectoparasites,
although not disabling, are considered a nuisance
and can transmit disease.
Lindane (Kwell) (Old name: Gamma
ACTION AND USE. Lindane is a pedi-
culocide used in the treatment of Pediadosis
capitis (head lice) and Phthirus pubis (crab lice).
It is also indicated for scabies. Use with caution,
especially in infants, children, and pregnant
women, since it penetrates human skin and has
the potential for systemic poisoning. This drug
is irritating to the eyes and should be discontinued
immediately if local irritation occurs.
USUAL DOSE. As a 1 percent cream, lo-
tion, or shampoo, it is for topical use only. A
single application is usually sufficient to kill
parasites and their eggs, but it may be repeated
in 7 days.
ACTION AND USE. This is a scabicide in-
dicated for the treatment of scabies (Sarcoptes
scabiei); it also has an antipruitic effect. Keep
away from the eyes and mouth, and do not apply
to inflamed skin.
USUAL DOSE. For topical use only, it is
available in a 10 percent cream or lotion.
Thoroughly massage into the skin of the whole
body from the chin down for scabies treatment.
A second application is often advisable in 24
ACTION AND USE. Metronidazole is ef-
fective in the treatment of all forms of amebiasis.
It is also used as a trichomonacide.
USUAL DOSE. For amebiasis, give 500 to
750 mg three times daily for 5 to 10 days. For
trichomoniasis, give 2 g as a single dose or 250
mg three times daily for 7 days. Take with food
or milk. NOTE: DO NOT DRINK ANY
ALCOHOLIC BEVERAGES; IT MAY CAUSE
A DISULFRAM REACTION. Metronidazole
is contraindicated in pregnant women during the
Chloroquine Phosphate (Aralen)
ACTION AND USE. Chloroquine phos-
phate is the drug of choice in the treatment of
acute malarial attacks and severe disease and in
the prevention and suppression of malaria in
USUAL DOSE. It is generally administered
once a week while in an endemic area as a pro-