be used by trained personnel. Inspect the vaccina-
tion site 6 to 8 days after vaccination and inter-
pret the response as follows:
1. A primary vaccination, if successful, shows
a typical vesicle. If none is observed, check
the vaccination procedures and repeat the
vaccination with another lot of vaccine un-
til a successful result is obtained. Record
reactions as successful or unsuccessful.
2. Following revaccination, two possible
responses may be noted:
Major reactionA vesicular or
pustular lesion, or an area of definite
palpable induration or congestion sur-
rounding a central lesion, which may
crust or ulcer. This reaction indicates
that virus multiplication has most likely
taken place and that the revaccination
Equivocal reactionAny other reac-
tion should be regarded as equivocal.
These responses may be the conse-
quence of immunity adequate to
suppress virus multiplication or may
represent only allergic reactions to an
inactive vaccine. If an equivocal re-
action is observed, recheck the revac-
cination procedures and repeat the
revaccination one time.
Vaccine (killed and dried with
The typhoid vaccine consists of one 0.5 ml
dose which is given subcutaneously. The vaccine
will be administered to all active duty personnel
at their first permanent duty station. Alert Forces
will be revaccinated every 3 years. Never give the
typhoid vaccine intradermally.
The basic series consists of two 0.5 ml primary
injections, given intramuscularly 1 to 2 months
apart. A third reinforcing injection of 0.1 ml is
given approximately 12 months after the second
dose when there is reliable evidence that the per-
son has never received the immunization prior to
entering the service. Reimmunization is required
every 10 years or may be ordered after a serious
injury or burn.
Trivalent Oral Poliovirus Vaccine
This live trivalent vaccine is given orally either
in distilled unchlorinated water, in simple syrup,
or by a sterile medicine dropper. Keep the vac-
cine frozen until needed and use only for 7 days
after the bottle is opened. Never refreeze the vac-
cine. Give a single dose of trivalent oral poliovirus
vaccine to all recruits or officers who have not
had it within 3 days of recruit training or during
officer indoctrination programs.
The influenza virus vaccine must be given an-
nually, at the start of the respiratory disease
season (usually October in the northern
hemisphere), to all recruits, officer candidates,
midshipmen, and members of the Navy and
Marine Corps. The vaccine is sometimes offered
to other personnel and dependents on a volun-
tary basis. All active duty Navy and Marine Corps
personnel are designated to receive the immuniza-
tion. Unless otherwise specified, give one injec-
tion of 0.5 ml intramuscularly.
Yellow Fever Vaccine
This vaccine is given to all Navy and Marine
Corps Personnel and also to all other DOD per-
sonnel who must travel to a yellow fever endemic
area. A single 0.5 ml injection is given sub-
cutaneously. If the vaccine is received in concen-
trated form, it must be diluted in a 1:10 ratio.
Reimmunization is required every 10 years.
This vaccine will only be given on a case by
case basis to personnel who must travel to coun-
tries still requiring the vaccine. A 0.5 ml dose given
either subcutaneously or intramuscularly is re-
quired. Reimmunization, if required, will be given
at 6-month intervals.
The basic series of plague vaccine consists of
two doses. The first is 0.5 ml given intramus-
cularly and the second is 0.2 ml given in-
tramuscularly 3 months after the first dose. This
vaccine is given to all Navy personnel assigned to
operational billets with the Fleet Marine Forces.
It may be given under special circumstances in
very high plague endemic areas or for high risk